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Can J Physiol Pharmacol ; 101(6): 268-285, 2023 Jun 01.
Artículo en Inglés | MEDLINE | ID: covidwho-2260515

RESUMEN

The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) from China in December 2019 led to the coronavirus disorder 2019 pandemic, which has affected tens of millions of humans worldwide. Various in silico research via bio-cheminformatics methods were performed to examine the efficiency of a range of repurposed approved drugs with a new role as anti-SARS-CoV-2 drugs. The current study has been performed to screen the approved drugs in the DrugBank database based on a novel bioinformatics/cheminformatics strategy to repurpose available approved drugs towards introducing them as a possible anti-SARS-CoV-2 drug. As a result, 96 approved drugs with the best docking scores passed through several relevant filters were presented as the candidate drugs with potential novel antiviral activities against the SARS-CoV-2 virus.


Asunto(s)
COVID-19 , SARS-CoV-2 , Humanos , Reposicionamiento de Medicamentos/métodos , Antivirales/farmacología
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